Bixori-60 tablet contains etoricoxib. It is a selective COX-2 inhibitor. Cyclo-oxgenase-2 inhibitor plays a major role in joint inflammation and pain. Etoricoxib produces its pharmacological action by inhibiting COX-2. It also possesses anti-arthritic property.
- In acute pain and gout
- In osteoarthritis
- Ankylosing spondylitis
- Chronic low back pain
- Acute gouty arthritis
- Acute pain
It is a non steroidal anti-inflammatory drug which produces its pharmacological action by inhibiting the isoform 2 of cyclo-oxgenase which is involved in inflammatory process. It inhibits prostaglandin generation from arachidonic acid.
After oral administration the drug is 100% absorbed in the body
About 90% of the drug is bound to plasma protein. The metabolism of the drug is through liver by CYP3A4.
The drug is excreted through urine and feces
- Hypersensitivity to non steroidal anti-inflammatory drug
- Peptic ulcer
- Inflammatory bowel disease
- Severe congestive heart failure
- Pregnant patients
- Patients with allergic disorders
- Renal impairment
- Cardiac diseases
- Hepatic impairment
- In geriatrics patients