Eclogesic SP 2018-06-04T10:51:11+00:00

Eclogesic SP contains Aceclofenac, Paracetamol and Serratiopeptidase combination of drugs.

Aceclofenac is a phenylacetic acid derivative which produces its action on inflammatory mediators. It is a glycolic acid ester of diclofenac.

Paracetamol is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.

Serratiopeptidase

It is a proteolytic enzyme which is produced by enterobacterium Serratia sp. It is a chemical which is obtained from silk worm.

  • Acute pain
  • Analgesic
  • Anti-pyretic
  • Migraine headaches
  • Ankylosing spondylitis
  • Rheumatoid arthritis
  • Osteoarthritis
  • Migraine
  • Headache
  • Fibromyalgia

Twice daily

Aceclofenac

It is a NSAID which produces its action by blocking COX-1 which is involved in inflammatory processes. This inflammatory mediators produces response to any injury and cause pain and swelling. It is a glycolic acid ester of diclofenac.

Paracetamol

It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.

Serratiopeptidase

It causes hydrolysis of histamin, bradykinin and serotonin. It produces proteolytic and fibrinolytic effect. This is achieved by dissolving the complement (specific proteins responsible for inflammation) and increasing the plasmin activity by inhibiting the plasmin inactivators.

Aceclofenac

Absorption

After oral administration it is well absorbed in the body.

Distribution

About 99.7% of the drug is bound to plasma protein. It produces its action  by concentrating in synovial fluid. The drug is metabolized in liver as 4-hydroxyaceclofenac.

Excretion

It is excreted as conjugated metabolites through urine.

Paracetamol

Absorption

It has rapid and complete absorption

Distribution

The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.

Excretion

About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.

Serratiopeptidase

It binds to α2-macroglobulin in the blood in a 1:1 ratio. It produces its effects on the site of inflammation and infection and produces its effect as in reduction of pain and swelling.

  • Hypersensitivity to any of the component present in the drug
  • Patients with asthma, bronchospasm or acute rhinitis
  • Renal impairment
  • Patient with the history of peptic ulcer
  • Liver failure
  • Liver problems
  • Serious Kidney Problems
  • Cautiously used in epileptic patients and patients with convulsions
  • Lower dose should be used in patients with diarrhea
  • Ulcerative colitis
  • Crohn’s disease
  • Elderly Patients
  • Any allergies
  • Liver disease
  • Alcohol abuse