Muscoside 4mg contains thiocolchicoside. It is a sulphurated semi-synthetic derivative of colchicoside. It is a myorelaxant, which acts as GABA-A receptor antagonist. It also has powerful convulsant activity and not to be used in seizures patients.
- Degenerative vertebral disorder with painful spasm
- Lower back pain
- Dorsal pain
- Traumatological and neurlogical disorders
- Muscle spasm
The drug produces its action by inhibiting the recombinant human strychnine-sensitive glycine receptors. It also causes inhibition of human nicotine acetylcholine receptors. It produces its action as muscle relaxant and have GABA-mimetic and glycinergic actions. This produces reduce in spasticity.
After oral administration it is initially not detected in the plasma. One metabolite which is active is SL18.0740. the maximum plasma concentration occurs in 1hr.
After oral administration it is well absorbed and it is bound to plasma. The volume of distribution is more for thiocolchicoside to produce pharmacological action. The metabolism of the drug is in intestine. In intestine the drug is glucuroconjugated to produce the pharmacological action.
Nearly about 75% of the drug is excreted in feces and about 20% of the drug is excreted in urine. The whole drug after administration is absorbed and not excreted as unchanged form.
- Hypersensitivity to thiocolchicoside
- It is not to be used in the patients with flaccid paralysis and muscular hypoptonia
- Contraindicated in patients with congenital galactosemia and fructose intolerance
- Cautiously used in epileptic patients and patients with convulsions
- Lower dose should be used in patients with diarrhea