Muscoside-AP 2019-10-01T15:17:56+00:00

Aceclofenac NSAID, Analgesic, Antiinflammatory, Anti arthritic.

Paracetamol Acetanilide derivative, Non narcotic Analgesic,Antipyretic.

Thiocolchicoside  A GABA-A antagonist,semi-synthetic colchicoside(natural compound) derivative, A centrally acting muscle relaxant.

  • Osteoarthritis 
  • Ankylosing spondylitis 
  • Painful spasm of Musculoskeletal & Neuromuscular 
  • Sciatica and Neck & Shoulder Pain 
  • Acute Low back pain, Post-operative

Twice a day or as directed by physician

Aceclofenac – It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). 

Paracetamol- Paracetamol has analgesic and antipyretic action. It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis. 

Thiocolchicoside- Thiocolchicide is a GABA-A receptor antagonist, which binds to GABA-A and strychnine sensitive glycine receptors. This results the reduction of spasticity. It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.

Aceclofenac

Absorption– It is rapidly and completely absorbed after oral administration 
Distribution– Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac  penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma. 
Metabolism– Metabolized into metabolites in the liver. Main metabolite is 4-hydroxyaceclofenac 
Excretion– It is excreted through urine mainly as conjugated hydroxymetabolites 

Paracetamol

Absorption: Paracetamol  is rapidly and completely absorbed after oral administration. 
Distribution: It is distributed mostly in the body in unbound form. 
Metabolism: It is extensively metabolised in the liver. 
Excretion: Excreted in the urine. 


Thiocolchicoside

Absorption : Oral bioavailability is ~25% 

Distribution: apparent volume of distribution of thiocolchicoside is approximately 42.7 L 

Metabolism: rapidly absorbed after oral administration and metabolized into 3 main metabolites 1st in intestines & further metabolized in circulation 

Elimination: metabolites found in either feces (~79 %) or in urine 20%.

  • Hypersensitivity
  • Impaired hepatic or renal organ function
  • Severe heart failure or severely
  • patients with diarrhea
  • Hepatic porphyria 
  • Blood disorders 
  • Crohn`s disease 
  • Decreased heart function 
  • History of peptic ulcers 
  • Inflammation of the bowel and back passage 
  • Mildly decreased kidney function 
  • Recent major surgery 
  • Decreased liver function