Tolpee-150 tablet contains tolperisone. It is a piperidine derivative which is centrally acting muscle relaxant. It is mainly used for the treatment of spasticity of neurological origin and muscle spasm due to rheumatoid conditions. It is a ion channel blocker which blocks the seven isoforms of sodium.
- Muscle spasm
- Chronic pain
50-150mg thrice a day
Tolperisone produces its pharmacological action by blocking the calcium and sodium channels. It exerts its inhibitory action on spinal reflex. It increases the blood supply to skeletal muscles. It also causes preferential antinociceptive activity against thermal stimulation which contributes to local anesthetic action.
The drug after oral administration gets absorbed from the body achieving high plasma concentration in 0.5-1hr.
The drug is well distributed in the body by following hepatic first pass metabolism.
About 85% – 98% of the drug is excreted through kidney
Not to be recommended in the patients with myasthenia gravis
• Caution needed for children less than 1 year
• During pregnancy and breastfeeding.