Tolpee-P tablet contains tolperisone and paracetamol.
Tolperisone is a piperidine derivative which is centrally acting muscle relaxant. It is mainly used for the treatment of spasticity of neurological origin and muscle spasm due to rheumatoid conditions. It is a ion channel blocker which blocks the seven isoforms of sodium.
Paracetamol is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
- Muscle spasm
- Chronic pain
50-150mg thrice a day
Tolperisone produces its pharmacological action by blocking the calcium and sodium channels. It exerts its inhibitory action on spinal reflex. It increases the blood supply to skeletal muscles. It also causes preferential antinociceptive activity against thermal stimulation which contributes to local anesthetic action.
Paracetamol inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
The drug after oral administration gets absorbed from the body achieving high plasma concentration in 0.5-1hr.
The drug is well distributed in the body by following hepatic first pass metabolism.
About 85% – 98% of the drug is excreted through kidney
It has rapid and complete absorption
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
- Not to be recommended in the patients with myasthenia gravis
- Liver Problems
- Serious Kidney Problems
- Caution needed for children less than 1 year
- During pregnancy and breastfeeding
- Hypersensitivity to any of the ingredient