Zymotryp -DP is a combination of trypsin, chymotrypsin, Diclofenac potassium and paracetamol.
Trypsin is a digestive enzyme which break down protein in small intestine.
Chymotrypsin is an enzyme which accelerates the chemical reaction occurring in the body. It is also breathed or inhaled so as to reduce pain and swelling.
It is NSAID and applied to skin to reduce the inflammation and to reduce pain.
It is also known as acetaminophen and is widely used as over the counter analgesic and anti-pyretic. It is a mild analgesic which causes relief in mild headaches and other aches and pains. In combination with other drugs like opioid analgesic, paracetamol is used in the management of post surgical pain and severe pain.
- It reduces the tissue destruction in burn patients
- Cataract surgery
- Orally taken in hand fractures
As directed by physician
After administration these enzymes are taken up by circulating enzyme inhibitors. These circulating enzyme inhibitors are alpha antitrypsin and alpha 2 macroglobulin. Taking up causes rise in the inhibitory enzyme levels which causes fibrinolytic shut down and also maintains the inflammatory edema. It also facilitates to open the blocked microcirculation and causes increase in the healing process.
It causes the inhibition of prostaglandin synthesis by causing the inhibition of COX. It also possesses bacteriostatic activity by inhibition of bacterial DNA synthesis.
It inhibits the synthesis of prostaglandin synthesis by competing with arachidonic acid for the active site of COX.
It is a serine endopeptidase which helps in catalysing the cleavage of peptide bonds. it helps in regulation of cytokinase levels and also scavenges the free radical.
After dermal application it is well absorbed by the body about 100%. The drug follows first pass metabolism so 50% of the drug is systematically available. The mean absolute bioavailability is 55% and Tmax is 2.3 hr.
The Vd is about 1.4l/kg. About 99% of the drug is bound to protein. The diclofenac converts to its metabolites like 4′-hydroxy-, 5-hydroxy-, 3′-hydroxy-, 4′,5-dihydroxy- and 3’hydroxy-4′-methoxy-diclofenac.
The drug is excreted through urinary and biliary secretion.
It has rapid and complete absorption
The protein binding of the drug is about 25%, it undergoes glucuronidation in liver.
About 80% of acetaminophen is excreted in the urine after conjugation and about 3% of the drug is excreted unchanged.
- Hypersensitivity to any ingredient of the drug
- Blood coagulation disorder
- Third trimester of pregnancy
- Patients with GI bleeding
- Patients with pre-existing hepatic porphyria
- Liver Failure
- Liver Problems
- Hepatic failure
- Renal failure
- Pre-existing asthma
- Any allergies